Study Provides New Insight to Antidepressant's Effect on Immune System

According to the National Network of Depression Centers, 1 in 5 Americans have firsthand experience of mood disorders, including depression. Depression can be a particularly intrusive disorder and disrupt an individual's life for weeks, months or years. Most people know at least one person who has been affected by this condition. Despite the relative prevalence of depression, the causes and chemistry behind the disorder are still steeped in mystery. Successful treatment of major depression can be pharmaceutical, psychological or, commonly, both. Many approaches have been attempted with a wide variety of success rates.

As far as pharmaceutical aids are concerned, they have proven to be effective in many cases, but how they actually weave their magic still holds a certain degree of mystery.The immune systems of people with depression have been found to produce an increased inflammatory response. This inflammation can lead to the production of neurotoxic compounds that kill brain cells. In a negative cycle, depression leads to inflammation in the brain, which further increases the feelings of depression.

" I wanted to prove antidepressant drugs have an impact on ones immune response" explained Dr. Angelos Halaris, lead author of the study and professor at the Department of Psychiatry and Behavioral Neurosciences of Loyola University Chicago Stritch School of Medicine

The study looked at patients with severe depression who were prescribed escitalopram, a common form of SSRI. Of the patients that completed the trial, 80% reported at least some degree of remission in their depressive symptoms.

To investigate the immunological component, the team took samples of the patients' blood and measured the levels of nine chemicals associated with an immune reaction. Of the nine substances, eight were found to be elevated above normal levels in the depressed participants.

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